Journal: International Journal of Medical Sciences

Article Title: Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats

doi: 10.7150/ijms.14769

Figure Lengend Snippet: Masson's trichrome staining of cardiac tissue sections. Histopathological analysis of cardiac tissue sections of the left ventricle from the control rats, the high-fat diet-induced obese rats, the high-fat diet-fed rats treated with low dose, medium dose and high dose of multi-strain probiotics. White arrow: site of collagen accumulation.

Article Snippet: Multi-strain probiotic powder ( Lactobacillus rhamnosus: Pediococcus acidilactici : Bifidobacterium adolescentis ; 1: 1: 1) was produced by freeze-drying and obtained from New Bellus Enterprise Co., Ltd (Tainan, Taiwan).

Techniques: Staining, Control, Probiotics

Journal: International Journal of Medical Sciences

Article Title: Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats

doi: 10.7150/ijms.14769

Figure Lengend Snippet: Fibrosis-related protein expression analysis via Western blot. The fibrosis-related protein levels were increased in the left ventricular tissue of high-calorie diet-induced obese rats, whereas treatment with different doses of multi-strain probiotics reduced these fibrosis-related proteins. (A) Western blots for the fibrosis pathway proteins. Quantitative analysis of the expression levels of (B) MMP2 or (C) TGF-β normalized to those of tubulin, #P<0.05, ##P<0.01 or ###P<0.001: the mean values were significantly different from those of the control group.

Article Snippet: Multi-strain probiotic powder ( Lactobacillus rhamnosus: Pediococcus acidilactici : Bifidobacterium adolescentis ; 1: 1: 1) was produced by freeze-drying and obtained from New Bellus Enterprise Co., Ltd (Tainan, Taiwan).

Techniques: Expressing, Western Blot, Probiotics, Control

Journal: International Journal of Medical Sciences

Article Title: Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats

doi: 10.7150/ijms.14769

Figure Lengend Snippet: Autophagy early stage-related protein expression analysis via Western blot. The autophagy-related protein levels were increased in the left ventricular tissue of high-calorie diet-induced obese rats, whereas treatment with different doses of multi-strain probiotics reduced these fibrosis-related proteins. (A) Western blots for the fibrosis pathway proteins. Quantitative analysis of the expression levels of (B) LC3B or (C) ATG7 normalized to those of tubulin, #P<0.05, ##P<0.01 or ###P<0.001: the mean values were significantly different from those of the control group.

Article Snippet: Multi-strain probiotic powder ( Lactobacillus rhamnosus: Pediococcus acidilactici : Bifidobacterium adolescentis ; 1: 1: 1) was produced by freeze-drying and obtained from New Bellus Enterprise Co., Ltd (Tainan, Taiwan).

Techniques: Expressing, Western Blot, Probiotics, Control

Journal: International Journal of Medical Sciences

Article Title: Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats

doi: 10.7150/ijms.14769

Figure Lengend Snippet: ICH staining of cardiac tissue sections. Histopathological analysis of cardiac tissue sections of the left ventricle from the control rats, the high-fat diet-induced obese rats, the high-fat diet-fed rats treated with low dose, medium dose and high dose of multi-strain probiotics. Brown color: site of LC3B expression.

Article Snippet: Multi-strain probiotic powder ( Lactobacillus rhamnosus: Pediococcus acidilactici : Bifidobacterium adolescentis ; 1: 1: 1) was produced by freeze-drying and obtained from New Bellus Enterprise Co., Ltd (Tainan, Taiwan).

Techniques: Staining, Control, Probiotics, Expressing

Journal: International Journal of Medical Sciences

Article Title: Multi-Strain Probiotics Inhibit Cardiac Myopathies and Autophagy to Prevent Heart Injury in High-Fat Diet-Fed Rats

doi: 10.7150/ijms.14769

Figure Lengend Snippet: Hypertrophy-related protein expression analysis via Western blot. The autophagy-related protein levels were increased in the left ventricular tissue of high-calorie diet-induced obese rats, whereas treatment with different doses of multi-strain probiotics reduced these fibrosis-related proteins. (A) Western blots for the fibrosis pathway proteins. Quantitative analysis of the expression levels of (B) ERK5, (C) MEK5, (D) uPA and (E) ANP normalized to those of tubulin, #P<0.05, ##P<0.01 or ###P<0.001: the mean values were significantly different from those of the control group.

Article Snippet: Multi-strain probiotic powder ( Lactobacillus rhamnosus: Pediococcus acidilactici : Bifidobacterium adolescentis ; 1: 1: 1) was produced by freeze-drying and obtained from New Bellus Enterprise Co., Ltd (Tainan, Taiwan).

Techniques: Expressing, Western Blot, Probiotics, Control

Journal: Journal of Translational Medicine

Article Title: Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections

doi: 10.1186/s12967-024-05587-9

Figure Lengend Snippet: Immunomodulatory and pathological implications to fight against diseases using favourable microbes and nutraceuticals (dietary fibres, vitamins, polyunsaturated fatty acids and flavonoids)

Article Snippet: NCT04877704 , The effects of symprove, a multi-strain Probiotic, as an Adjuvant in the Management of COVID-19 in Hospitalized Patients , Symprove probiotics , Length of Hospital Stay, intestinal inflammation, symptoms recovery in 3 months.

Techniques: Probiotics, Control, Infection, Bacteria, Concentration Assay, Synthesized, Activation Assay, Inhibition, Produced, Adjuvant, Activity Assay, Phospho-proteomics, Translocation Assay

Journal: Journal of Translational Medicine

Article Title: Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections

doi: 10.1186/s12967-024-05587-9

Figure Lengend Snippet: Properties of Nutraceuticals and Pharmacological interventions to regulate the protective immune activities in alveolar and gut cell linings. A probable modulatory effect of probiotics with supplements to build ILC 3 homeostasis in gut and the functional integrity of the other body organs [ , , – , ]

Article Snippet: NCT04877704 , The effects of symprove, a multi-strain Probiotic, as an Adjuvant in the Management of COVID-19 in Hospitalized Patients , Symprove probiotics , Length of Hospital Stay, intestinal inflammation, symptoms recovery in 3 months.

Techniques: Probiotics, Functional Assay

Journal: Journal of Translational Medicine

Article Title: Nutraceuticals and pharmacological to balance the transitional microbiome to extend immunity during COVID-19 and other viral infections

doi: 10.1186/s12967-024-05587-9

Figure Lengend Snippet: The interventional studies are being carried out using probiotics in COVID-19 individuals with expected outcome (ClinicalTrials.gov—U.S. National Library of Medicine)

Article Snippet: NCT04877704 , The effects of symprove, a multi-strain Probiotic, as an Adjuvant in the Management of COVID-19 in Hospitalized Patients , Symprove probiotics , Length of Hospital Stay, intestinal inflammation, symptoms recovery in 3 months.

Techniques: Probiotics, Infection, Maltodextrin, Starch, Capsules, Bacteria, Activation Assay, Biomarker Discovery, Adjuvant